P
H D - M
O L E C U L A R &
C E L L U L A R
Ph.D. in Toxicology
- Overview
Ph.D. in Toxicology
-
General Toxicology Option
Ph.D. in Toxicology -
Environmental Toxicology
Concentration
Mailing
address:
Department of Environmental
and Molecular Toxicology
Box 7633, NC State University
Raleigh, NC 27695-7633
Shipping
address:
Suite 1104, 850 Main Campus Dr.
Raleigh, NC 27606
Phone
919.515.2274
Fax 919.515.7169
PhD
IN TOXICOLOGY
MOLECULAR & CELLULAR TOXICOLOGY (MCT) CONCENTRATION
Current Students and Recent Graduates in MCT
The objective of the Molecular and Cellular Toxicology is to provide students with the skills and knowledge necessary to investigate and elucidate how environmental toxicants/cellular stressors contribute to toxicity and influence disease outcomes. PhD students acquire a solid background by completing coursework in toxicology, molecular biology, pharmacology, statistics, and pathology. Pre/postdoctoral trainees receive training in ethics, grant writing and oral communication skills. Pre/postdoctoral trainees participate in a weekly departmental seminar program both as members of the audience and as presenters. Each semester a former trainee is invited back to the department to present a seminar and to share their career experiences with current trainees.
If
you have questions about the MCT Concentration or would like to arrange
a visit to our campus please contact Dr.
Robert C. Smart,
the Director of the MCT concentration. Complete contact information
for all faculty in the Department of Environmental and Molecular Toxicology
may be found on the People/Faculty page.
The broad research theme is to understand how toxicants and cellular stressors perturb cellular signaling pathways and deregulate gene expression and how this contributes to toxicity and human disease outcomes. Specific environmental-associated human diseases/conditions such as asthma, lung fibrosis, reproductive/endocrine abnormalities, developmental abnormalities and cancer as well as reactive oxygen species (ROS)-related toxicity are the focal molecular/cellular research areas. Examples of types of environmental agents that are being investigated include environmental carcinogens, pesticides, particulates, metals, endocrine disrupters and nanoparticles. For more information about MCT faculty research interests, visit the Molecular and Cellular Research page.
Core course requirements for all Ph.D. students
| TOX 701 | Fundamentals of Toxicology (3 credits) |
| TOX 710 | Molecular & Biochemical Toxicology (3 credits) |
| BCH 553 | Biochemistry of Gene Expression(3 credits) |
| CBS 762 | Principles of Pharmacology (3 credits) |
| ST 511(b) | Experimental Statistics for Biological Sciences (3 credits) |
| TOX 801(c) | Toxicology Seminar (1 credit/Semester) |
| TOX 820 | Responsibility in Science (1 credit) |
(a)
Students who have no previous Biochemistry should also enroll in BCH 451
- Principles of Biochemistry
(b) Another graduate-level statistics course can be substituted with approval
of the student's committee
(c) Enrollment is required for each semester registered while in Doctoral
Program (6 credits minimum)
Research requirements for all Ph.D. students
| TOX 895 | Doctoral Dissertation Research (6 credits minimum) |
| TOX 896 | Summer Dissertation Research (as needed) |
| TOX 899 | Doctoral Thesis Preparation (as needed) |
Additional requirements for Molecular & Cellular Toxicology Concentration
| CBS 795 | General Pathology I (3 credits) |
| Electives | 6 credits related to Molecular and Cellular Toxicology must be selected |
Normally a total of 72 credit hours is required, with the majority of these credits being dissertation research. See the Graduate School web page for specific credit hour and residency requirements.
Current Students and Recent Graduates in MCT
The heart and soul of the MCT concentration are the current and former students. Listed below are the names of recent graduates of the MCT concentration along with their thesis titles, the MCT laboratories in which they conducted their doctoral research, and their current research positions. You will also find a list of current students and their e-mail addresses, their areas of research and the laboratories in which they are studying. Feel free to contact any MCT student for information about their specific research project, their laboratory, or the MCT concentration. Complete contact information for all current students may be found on the People/Student page.
| Year Graduated | Graduate Name & E-mail Dissertation Title/Faculty Advisor |
Current Position, Organization, Address Postdoctoral Position if prior to current) |
| 2009 | Edward L. Croom
croom.edward@epamail.epa.gov Human hepatic expression of CTP2B6: developmental pattern and in vitro bioactiviation of chlorpyrifos/Hodgson & Rose |
Postdoctoral Fellow, USEPA NHEEL, RTP, NC 27711 |
| 2009 | Jae Young Kim
jkim@burnham.org TAK1 is a Central Mediator of NOD2 Signaling and is Essential for Intestinal Epithelial Cell Protection against Chemical-Induced Colitis/ Ninomiya-Tsuji |
Postdoctoral Fellow, Burnham Institute for Medical Research LaJolla, CA 92037 |
| 2009 | Elizabeth E. Anderson Thompson
andere3@hotmail.com Localization of C/EBPalpha within human skin, its response to UVB-light, and identification of mutations within the gene in human basal and squamous cell carcinomas/Smart |
|
| 2008 | Kari Loomis
karilct@msn.com Signal transduction and carcinogenesis/Smart | Assistant
Professor, Mars Hill College Biololgy PO Box 370 Mars Hill, NC 28754 |
| 2008 | Rachel N. Murrell
rnmurrel@suddenlink.net
The Effects of Brevetoxin and Brevetoxin Antagonists on Jurkat E6-1 Cell Proliferation, Survival and Gene Expression/Gibson & Shea |
Postdoctoral Fellow, University of North
Carolina-Wilmington/East Carolina University Greenville, NC 27834 |
| 2007 | Leslie M. Tompkins, Ph.D.
ltompkin@rx.umaryland.edu Identification and characterization of a novel promoter for steroid and xenobiotic receptor (SXR) variant 2/Wallace |
Postdoctoral Fellow, University of Maryland
School of Pharmacy Department of Pharmaceutical Sciences 20 Penn St., Baltimore, Maryland 21201-1075 |
| 2007 | Kiros Hailemariam, Ph.D.
kawmhf@yahoo.com HIPK2 is a Novel ATF1 Kinase and Regulates Transcription of Human Ferritin H Gene through an Antioxidant Responsive Element/Tsuji |
ORISE Fellow, Oak Ridge Institute of Science and Education, USFDA College Park, MD 20740 |
| 2007 | Sarah J. Ewing, Ph.D.
sjf157@psu.edu Functional relationship between Ras and C/EBP-beta in cell survival and sking tumorigenesis/Smart (graduate of Comparative Biological Sciences program) |
Assistant Professor, Gannon University
Biology Director of Pre-Professional Programs 109 Universtiy Square Erie, PA 16563 |
| 2007 | Amber Goetz, Ph.D.
amber_kristina.goetz@syngenta.com Toxicogenomic study of triazole antifungal modes of action/Dix & Hodgson |
Technical Expert II, Syngenta Crop Protection, Inc. 410 Swing Rd, Greensboro, NC 27409 |
| 2007 | Elizabeth (Libby) MacKenzie, Ph.D.libby.mackenzie@gmail.com Regulation of ferritin H in the cellular response to stress/Tsuji |
Medical Writer/Editor, Education and Training Systems International (ETSI) Chapel Hill, NC |
| 2007 | Christopher Brynczka, Ph.D.
cbrynczka@gmail.com Nerve growth factor regulation of transcription factor p53 activity/Merrick |
Research Fellow, Harvard School of Medicine
Massachusetts General Hospital Department of Pediatric Hematology & Oncology 55 Fruit Street, Boston, MA 02114 |
| 2007 | Wei-Chun HuangFu, Ph.D.
clarehf@hotmail.com Osmotic Stress Activates JNK While Blocking NF- k B Pathway, and Modulates Immune Responses/Ninomiya-Tsuji |
Postdoctoral Fellow, University of Pennsylvania Department of Animal Biology Room 316 Hill Pavilion,380 S University Avenue Philadelphia, PA 19104-4539 |
| 2006 | Jin-Ah Park, Ph.D.
jpark@hsph.harvard.edu Role of PKC delta in airway mucin secretion/Adler |
Research Fellow, Harvard School of Public Health Department of Environmental Health 665 Huntington Ave., Boston, MA 02115-6021 |
| 2006 | Jonathan P. Jackson, Ph.D.
jonathanj@cellzdirect.com The role of the nuclear Receptors CAR and PXR in the drug induced transcriptional regulation of murine CYP2C subfamily of cytochrome P450 monooxygenases/Goldstein & Rose |
Study Director, Cellz Direct 1624 Headway Circle, Suite 100, Austin, TX 78754 Postdoctoral, University of Arizona |
| 2006 | Steven Simmons, Ph.D.
simmons.steve@epa.gov Biochemical and Functional Analysis of Homeoprotein NKx3.1/Horowitz |
Principal Investigator, US EPA
RTP, NC 27711 |
| 2004 | Kyungsil Yoon, Ph.D.
kyoon@ncc.re.kr CCAAT/enhancer binding protein-alpha (C/EBP-alpha) is a DNA damage inducible P53 regulated mediator of the G1 checkpoint/Smart |
Research Scientist, National Cancer Center
Divison of Common Cancers Lung Cancer Branch, Korea Postdoctoral Fellow, Texas A&M University System Health Science Center |
| 2004 | John Couse, Ph.D.
couse@taconic.com The role of estrogen receptor-alpha and estrogen receptor-beta in the hyperluteinized mouse ovary/Korach & Smart |
Senior Manager, Taconic Contract Research Solutions University Place, Rensselaer, NY 12144 |
| 2004 | Jason Ralph Pirone, Ph.D.
jpirone@constellagroup.com Stochastic Modeling of Transcription Factor Binding Fluctuations/Smart & Elston |
Senior Biomathematician, Constella Health Sciences 3125 McGavran-Greenberg Hall Pittsboro Rd., Chapel Hill, NC 27312 |
| 2003 | Minsub Shim, Ph.D.
shim@niehs.nih.gov Proteasomal regulation of C/ERPalpha protein and diminished expression in squamous cell carcinomas/Smart |
Postdoctoral Fellow, NIEHS Laboratory of Molecular Carcinogenesis P.O. BOX 12233, (MD:D4-04) Research Triangle Park, NC 27709 |
| 2002 | Edward D. Karoly, Ph.D.
karoly.edward@epa.gov Mammalian monooxygenases and environmental chemicals/Rose & Hodgson |
Postdoctoral Fellow, US EPA USEPA Mailroom, MC580 Research Triangle Park, NC 27711 |
| 2002 | F. Javier Cisneros, DVM, Ph.D.
fjcisner@yahoo.com Epigenetic inheritance of 5-Aza-2'-deoxycytidine (5-AZA-Cdr) induced alterations/Branch |
Research Scientist, Charles River Laboratories
Horsham, PA Postdoctoral Fellow FDA National Center for Toxicological Research |
| 2001 | Karen L. Porter, Ph.D. klporter@mdanderson.org 17-beta-estradiol is abundant in skin and influences hair follicle cycle and mirex tumor promotion/Smart & Robinette |
Postdoctoral Fellow, University of Texas
Experimental Radiation Oncology M. D. Anderson Cancer Center, Houston, TX |
| 2000 | Barbara A. Wetmore, Ph.D.
bwetmore@thehamner.org Herbicide alachlor nasal carcinogenicity and hepatotoxicity involve site-specific bioactivation and oxidative stress/Meyer & LeBlanc |
Research Investigator, The Hamner Institutes for Health Sciences CIIT, Division of Toxicology and Preclinical Studies PO Box 12137, Research Triangle Park, NC 27709-2137 IRTA Postdoctoral Fellow, NIEHS |
| 2000 | Michael E. Viana, Ph.D.
mviana@dynamic.com A functional role for protein kinase C in epidermal Langerhans cells/Smart |
Toxicologist, Dynamic Corporation Durham, NC 27713 Postdoctoral Trainee, US EPA |
| 2000 | Hui-Qin Wang, Ph.D.
huiqin.wang@emdserono.com Overexpression of protein kinase C in the epidermis of transgenic mice results in striking alterations in phorbol ester-induced inflammation but nt tumor promotion/Smart |
Senior Scientist, Serono Research Institute
Rockland, MA Postdoctoral, Fox Chase Cancer Center |
| 1999 | Lynn M. Crosby, Ph.D. Mechanisms of potassium bromate-induced mesothelial carcinogenesis in the male F344 rat/DeAngelo |
|
| 1999 | Theresa Allio, Ph.D.
Theresa_Allio@vrtx.com The role of genomic instability and mutation hypersensitivity in tumor development/Preston & Smart |
Pharmacologist, USFDA Washington DC |
| 1998 | James G. Christensen, Ph.D. Dysregulation of apoptosis during nongenotoxic hepatocarcinogenesis in mice/Goldsworhy & Smart |
Senior Principal Scientist, Pfizer Pharmaceuticals San Diego, CA 92121 |
| 1998 | Christopher Saranko, Ph.D.
csaranko@envirocorp.com The roles of two epoxide metabolites in the mutagenicity of 1,3-butadiene/Recio |
Senior Toxicologist, Environ International Corp. 1900 N. 18th St., Suite 804, Monroe, LA 71201 |
| 1998 | Theresa S. Klose, Ph.D.
klosets@appliedbiosystems.com Polymorphisms, structure activity relationships and expression of the human CYP2Cs/Goldstein |
Genetic Systems Specialist, Applied Biosystems< Foster City, CA 94404 |
| 1998 | Nathan Cherrington, Ph.D.
cherrington@pharmacy.arizona.edu Murine hepatic flavin-containing monooxygenases (FMO):gender differences across species, developmental pattern and molecular cloning and expression in E. coli/Rose & Hodgson |
Associate Professor, University of Arizona
Dept. of Pharmacology and Toxicology Tucson, AZ 85721-0207 Postdoctoral, Kansas University Medical Center |
| 1997 | Hye-Sun Oh, Ph.D., D.A.B.T.
hyesun.oh@roche.com Role of estrogen receptor pathway and CCAAT/enhancer binding proteins in keratinocyte proliferation and differentiation/Smart |
Research Leader, Hoffman-La Roche Pharmaceuticals, Inc.
Non-Clinincal Drug Safety 340 Kingsland St., Bldg. 100/Rm 314, Nutley, NJ 07110 Postdoctoral Lecturer, Harvard Medical School |
| 1996 | Tae-Won Kim, Ph.D.
<TKim@isisph.com Mirex promotes a unique populatio of epidermal cells that cannot be distinguished by their mutant Ha-ras genotype/Smart |
Director of Toxicology, Isis Pharmaceuticals Carlsbad, CA 92008-7208 Postdoctoral, University of California at San Francisco |
| 1996 | David M. Owens, Ph.D.
do2112@columbia.com Genetic alterations cooperate with ras to influence premalignant progression in skin/Smart |
Assistant Professor, Columbia University
Dept. of Dermatology, College of Physicians and Surgeons New York, NY Postdoctoral, Imperial Cancer Research Fund, London, England |
| Year Enrolled | Student Name & E-mail Research Area/Faculty Advisor & Laboratory |
Education |
| 2004 | Rakesh Ranjan
rranjan@ncsu.edu Identification and characterization of signaling pathways involved in UVB induction of C/EBPalpha/ Smart |
Bachelor of Veterinary Science, A.N.G.R. Agriculture University. Hyderabad,INDIA |
| 2004 | Christopher Sistrunk
cmsistru@unity.ncsu.edu< The role of Skp2 in normal and neoplastic keratinocyte proliferation/Rodriguez-Puebla |
B.S. in Biology (Microbiology), Winston-Salem State University M.S. in Biology (Environmental Carcinogensis), North Carolina Central University |
| 2005 | Peter Broglie
pmbrogli@unity.ncsu.edu TAB2 regulates TNF-NF-KB pathway/Ninomiya-Tsuji |
B.S. in Biochemistry, LeMoyne College, New York |
| 2006 | John House
jshouse@ncsu.edu Research area to be determined/Smart |
BS in Cell and Molecular Biology, University of Tennessee-Knoxville M.S. in Mathematical Statistics, NC State University |
| 2006 | Bo-Wen Huang
bhuang@ncsu.edu Characterization of novel regulators of the ferritin H ARE/Tsuji |
B.S. in General Chemistry, National Changhua University of Education, Changhua, Tiawan MS.. in Biological and Life Sciences, National Chiao Tung University, Hsinchu, Taiwan |
| 2006 | Paul Ray
pdray@ncsu.edu Ferritin and Neurodegeneration/Tsuji |
B.S. in Toxicology, Northeast Louisiana University, Monroe, LA |
| 2007 | William Randall Lampe
wrlampe@ncsu.edu Effects of ozone on airway epithelial cell mucus production/Adler |
B.S. in Biology, University of North Carolina at Chapel Hill |
| 2007 | Samuel Suarez
scsuarez@ncsu.edu Investigating the role of accessory proteins in pol eta dependent 8-oxo-G bypass/McCulloch |
B.S. in Biochemistry, Tulane University, New Orleans, LA |
| 2008 | Brian Sayers
bcsayers@ncsu.edu Mechanisms of nanomaterial - Induced Cell Differentiation/Bonner |
B.S. in Toxicology, Northwestern University, Boston |
| 2008 | Ellen Glista
eeglista@ncsu.edu Growth factor regulation induced by nanomaterials/Bonner |
B.S. in Biochemistry, Mount Union College, Ohio |