P
h D - G E N E R A L O P T I O N
Ph.D. in Toxicology
- Overview
Ph.D. in Toxicology -
Environmental Toxicology
Concentration
Ph.D. in Toxicology -
Molecular and Cellular Toxicology
Concentration
Mailing
address:
Department of Environmental
and Molecular Toxicology
Box 7633, NC State University
Raleigh, NC 27695-7633
Shipping
address:
Suite 1104, 850 Main Campus Dr.
Raleigh, NC 27606
Phone
919.515.2274
Fax 919.515.7169
PhD
IN TOXICOLOGY
GENERAL TOXICOLOGY OPTION
General Toxicology Program Description
General Toxicology Course Requirements
Current Students and Recent Graduates in General Toxicology
General Toxicology Program Description
The
general toxicology option is designed for students who desire a broad
toxicology background and do not desire the specificity of the environmental
or the molecular and cellular concentrations. Students electing this
option may
want to pursue research in more traditional areas of toxicology including
fate and metabolism of toxicants, organ and cellular toxicity, endocrine
disruption, mechanisms of insecticide resistance, analytical toxicology,
or teratogenesis. Students in the General Toxicology Option may conduct
research in any area of Toxicology, but their coursework may reflect
a broader base of knowledge than those within the other two subdisciplines.
Students electing this option also have more flexibility to pursue minors
in topics such as Genetics, Chemistry, Entomology, Zoology, or Microbiology.
For a list of faculty and a description of their research programs please
visit our Research page.
General Toxicology Course Requirements
Core course requirements for all Ph.D. students
| TOX 701 | Fundamentals of Toxicology (3 credits) |
| TOX 710 | Molecular & Biochemical Toxicology (3 credits) |
| BCH 553 | Biochemistry of Gene Expression (3 credits) |
| CBS 762 | Principles of Pharmacology (3 credits) |
| ST 511(b) | Experimental Statistics for Biological Sciences (3 credits) |
| TOX 801(c) | Toxicology Seminar (1 credit/Semester) |
| TOX 820 | Responsibility in Science (1 credit) |
(a)
Students who have no previous Biochemistry should also enroll in BCH 451
- Principles of Biochemistry
(b) Another graduate-level statistics course can be substituted with approval
of the student's committee
(c) Enrollment is required for each semester registered while in Doctoral
Program (6 credits minimum)
Research requirements for all Ph.D. students
| TOX 895 | Doctoral Dissertation Research (6 credits minimum) |
| TOX 896 | Summer Dissertation Research (as needed) |
| TOX 899 | Doctoral Thesis Preparation (as needed) |
Additional requirements for General Toxicology Concentration
| CBS 795 | General Pathology I (3 credits) |
| Electives | 6 credits relevant to the student's area of research must be selected |
Normally a total of 72 credit hours is required, with the majority of these credits being dissertation research. See the Graduate School handbook for specific credit hour and residency requirements.
Current Students and Recent Graduates in General Toxicology
Current
and former students in General Toxicology provide the fuel (and the
blood, sweat and tears) for advancing the science
of toxiclogy. Listed below are
the names
of recent
graduates in General Toxicology along with their
thesis titles, the laboratories in which they conducted their
doctoral
research,
and their current research positions. You will also find a list of current
students and their e-mail addresses, their areas of research
and the laboratories in which they are studying. Feel free to contact
any General Toxicology student for information about their specific
research project, their laboratory, or the General Toxicology option. Complete
contact information for all current students may be found on the People/Student page. Visit
the Alumni section of our web to learn more
about NC State University Toxicology graduates and possibilities
for careers in toxicology.
Recent General Toxicology Graduates
| Year Graduated | Graduate Name & E-mail Dissertation Title/Faculty Advisor |
Current Position, Organization, Address Postdoctoral Position(if prior to current) |
| 2009 | Goran Bozinovic, Ph.D.
gbozino@ncsu.edu Physiology, Morphology, and Gene Expression of Sensitive and Resistant Fundulus Heteroclitus Embryos/Oleksiak |
|
| 2009 | Bethany Hannas, Ph.D.
bsreeve2@unity.ncsu.edu Mechanistic evaulation of the reproductive and developmental toxicty of nitrate and nitrite/LeBlanc |
Postdoctoral, EPA Research Triangle Park, NC 27709 |
| 2006 | Chad Blystone, Ph.D.
blystonecr@niehs.nih.gov Conazole Pesticide Disruption of Testicular Steroidogenesis during different stages of male development/LeBlanc |
Postdoctoral Fellow, NIEHS PO Box 12233, MD:C3-02, Research Triangle Park, NC 27709 |
| 2006 | J. Michael Sanders, Ph.D.
sander10@niehs.nih.gov Mechanisms of toxicity of polybrominated diphenyl ethers/Burka |
Biologist, NIEHS PO Box 12233, MD:C3-02, Research Triangle Park, NC 27709 |
| 2005 | Wendy N. Jefferson, Ph.D.
jeffers1@niehs.nih.gov Neonatal Exposure to the Phytoestrogen, Genistein Alters Ovarian Differentiation and Development/Newbold (NIEHS) & LeBlanc |
Biologist, NIEHS Developmental Endocrinology Group, Mail Drop E4-02 Research Triangle Park, NC 27709 |
| 2003 | Xueyan Mu, Ph.D.
peter.mu@covance.com Anti-ecdysteroidal Activity and Associated Toxicity of Environmental Chemicals in the Crustacean Daphnia magna/LeBlanc |
Study Director, Covance Laboratories, Inc. 9200 Leesburg Pike, Vienna, VA 22182-1699 Postdoctoral Fellow, US EPA |
| 2003 | Doug Anspaugh, Ph.D.
doug.anspaugh@basf.com Molecular genetics and enzyme regulation of Epoxide Hydrolases in the Cabbage Looper, Trichoplusia ni/Roe |
Biologist III, BASF Corporation Insecticide Mode of Action Group, Agricultural Products Division 26 Davis Dr., Research Triangle Park, NC 27709 Postdoctoral Fellow, US EPA |
| 2002 | Tara Lovekamp-Swan, Ph.D.
tswan@cato.com Molecular mechanisms of mono-(2-ethlyhexyl)phthalate (MEHP) -induced ovarian toxicity/LeBlanc & Davis |
Scientist, Cato Research Durham, NC 27713 Postdoctoral, Medical College of Georgia |
| 2002 | Meredith Gooding, Ph.D.
mgooding@winona.edu The Role of Steroid Metabolism in TBT-induced Imposex in lliyanassa obsoleta/LeBlanc |
Assistant Professor, Winona State University
Department of Biology PO Box 5838, Stark 209 Winona, MN 55987 Postdoctoral, University of Iowa |
| 2002 | Cynthia J. Wolf, Ph.D.
wolf.cynthiaj@epa.gov Mechanisms through which an environmental antiandrogen, vinclozolin, induces malformations of the male rat reproductive tract/LeBlanc & Gray |
Biologist, US EPA Reproductive Toxicology Division Research Triangle Park, NC 27711 Postdoctoral Fellow, US EPA |
| 2000 | Scott C. Coleman, Ph.D.
scott.coleman@cubist.com Comparative in vitro metabolism of chloracetamide herbicides and selected metabolites between rat and human liver microsomes/Hodgson & Rose |
Head, Mechanistic and Investigative
Toxicologyt, Cubist Pharmaceuticals 65 Hayden Ave., Lexington, MA 02421 |
| 2000 | Jeffrey S. Gillette, Ph.D. Polychlorinated biphenyls:isomer-specific effects on enzyme induction and steroid hormone metabolism/Rose & Hodgson |
|
| 2000 | Philip A. Poston, Ph.D.
pap2000@alumni.ncsu.edu New methods for the analysis of mercury and brevetoxins in toxicology studies/Shea & Leidy |
Lead Scientist, VA Dept. of General Services Newborn Screening 600 N. 5th St., Richmond, VA 23219=1439 |
| 2000 | Shana R. Dalton, Ph.D.
shana.dalton@covance.com Herbicide metolachlor effects on liver and thyroid endocrinology compared with CYP2B1/2/Meyer | Study Director, Covance Laboratories Inc.
Toxicology Dept. 3301 Kinsman Boulevard, Madison, WI 53704-2523 Postdoctoral, University of Nebraska Medical Center |
| 1999 | Stephen E. Graham, Ph.D.
graham.stephen@epa.gov Polycyclic aromatic hydrocarbons in Massachusetts Bay sediment: diagnostics, acumulation and source apportionment/Shea & Leidy | Physical Scientist, US EPA
Exposure Modeling and Research, NERL Research Triangle Park, NC 27711 Postdoctoral, US EPA |
| 1999 | C. Edwin Garner, Ph.D.
C.Edwin.Garner@astrazeneca.com Dermal absorption of polychlorinated biphenyls (PCBs) and the effect of PCB metabolites on estrogen metabolism/Matthews & Leidy |
Principal Scientist, AstraZeneca Drug Metabolism and Pharmacokinetics, Cancer and Infection Discovery Research 35 Gatehouse Road, Waltham, MA 02451 |
| 1999 | Vickie S. Wilson, Ph.D.
Wilson.Vickie@.epa.gov Physiological consequences of xenobiotic induced alterations in hepatic testosterone biotransformation/LeBlanc |
Research Biologist, US EPA NHEERL, Reproductive Toxicology Division Endocrinology Branch (MD-72) Research Triangle Park, NC 27711 Postdoctoral, US EPA |
| 1999 | Drew Luellen, Ph.D.
luellen@vims.edu Accumulation of PAHs and petroleum biomarkers in SPMDs and fish to discriminate petroleum sources/Shea & Leidy |
Environmental Data Research Specialist Virginia Institute of Marine Science(VIMS) Gloucester Point, VA |
| 1998 | Jana Cherrington, Ph.D. Effects of boric acid on the developing vertebral column and ribs in the CD-1 mouse in utero/Branch & Hodgson |
|
| 1998 | Chris Hofelt, Ph.D.
chris_hofelt@ncsu.edu Use of artificial substrates to monitor organic contamination in the aquatic environment/Shea |
Undergraduate Program Coordinator, NC State University Department of Environmental and Molecular Toxicology Box 7633, Raleigh, NC 27695 |
| 1998 | Louise Parks Saldutti, Ph.D. An investigation of the changes in steroid hormne metabolism and vitellogenin production as biomarkers of exposure and effect of endocrine disrupting chemicals/LeBlanc |
Research Scientist, Merck Postdoctoral,US EPA |
| 1998 | Anne V. Weisbrod, Ph.D.
weisbrod.av@pg.com Organochlorine exposure and potential effects in three northwest Atlantic whales/Shea |
Research Scientist, Procter & Gamble Sharon Woods Technical Center, 11530 Reed Hartman Highway Cincinnati, OH 45241 |
| 1997 | Robert Lange, Ph.D.
Anthralin-induced Oxidative Stress Modulates Inflammatory Cytokin Gene Expression in Human Keratinocytes and the BALS/c Mouse Ear |
|
| 1997 | Mark Wolff, Ph.D.
mark.wolff@sas.com Characterization and comparative pharmacological stuies of a functional y-aminobutyric acid (GABA) receptor cloned from heliothis virescens(noctuidae: lepidoptera)/Hodgson & Chalmers |
Systems Engineer, SAS Institute, Inc. SAS Health & Life Sciences SAS Institute, Inc., Cary, NC 27513 |
| 1997 | Lisa Bain, Ph.D.
lbain@clemson.edu Cellular trafficking of pesticides by glutathione-s-transferase mu and p-glycoprotein/LeBlanc |
Associate Professor, Clemson University Department of Biological Sciences, Toxicology Program Clemson, SC 29634 |
| 1997 | Kumar Penmetsa, Ph.D.
kumar.penmetsa@bmsi.com Applications of capillary electrophoresis in pesticide analysis and toxicology studies/Shea & Leidy |
Research Scientist, Bristol-Myers Corp. |
| 1996 | George Woodall, Ph.D. Effects of Dietary Casein Levels on the Activation and Metabolism of Promutagens by Rat Hepatic S9, Microsomes and Cytosol | Reserch Scientist, EPA |
| 1996 | Scott Knowles, Ph.D. Lead Disrupts Lipid Metabolism in Human, Rodent and Avian Species: Consequences for Immune Function and Disease Resistance |
|
| 1996 | Dong Ryu, Ph.D. Regulation of Cytochrome P450 Monooxygenase Isozymes CYP1A1, CYP1A2 and CYP1B1 by Piperonyl Butoxide and Acenaphthylene |
Professor, Seoul National University College of Veterinary Medicine Seoul Korea |
| 1996 | Donna Grant, Ph.D. A Comparison of the Distribution, Metabolism and Excretion of Two Benzoylphenylurea Pesticides, Diflubenzuron and Lufenuron in the Rat and Mouse |
|
| 1996 | James Greg Falls, Ph.D.
james.g.falls@gsk.com Hormonally regulated expression of Flavin-containing Monooxygenases (FMO) Isozymes; Cloning, Sequencing and cDNA-expression in E.coli of a Murine female-specific liver form, FM03 |
Research Scientist, GlaxoSmithKline 5 Moore Dr., RD9-2021, Research Triangle Park, NC 27709 |
Current General Toxicology Students
| Year Enrolled | Student Name & E-mail Research Area/Faculty Advisor & Laboratory |
Education |
| 2005 | Huiying Zhang
hzhang3@unity.ncsu.edu Lung injury and repair/Sannes |
B.S. in Biological Sciences, Ocean University, China M.S. in Biochemistry, Kent State University, Ohio |
| 2008 | Erin Kollitz
emkollitz@ncsu.edu Rotations/Kullman |
B.S. in Biology, Bard College, New York |
| 2008 | Erin Yost
eeyost@gmail.com Rotations/Kullman |
B.S. in Biology, University of Kentucky, Kentucky |
| 2009 | Renee Beardslee
renee_beardslee@gmail.com Rotations |
B.S. in Chemistry University of Michigan, Michigan |
| 2009 | Hann Tam
turihiril@gmail.com Rotations |
B.S. Biology University of Pittsburgh, |