Contact Us

Mailing address:
Department of Environmental and Molecular Toxicology
Box 7633, NC State University
Raleigh, NC 27695-7633

Shipping address:
Suite 1104, 850 Main Campus Dr.
Raleigh, NC 27606

Phone 919.515.2274
Fax 919.515.7169

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Patricia McClellan-Green, Ph.D.
Assistant Research Professor
Department of Environmental and Molecular Toxicology
North Carolina State University
Research Scientist
Division of Coastal System Sciences and Policy
Duke University


Phone: 252-222-6367
Fax: 252-222-6303
E-mail: pdmcclel@ncsu.edu

Education

BS and MS, Biology, East Carolina University
PhD, Toxicology, North Carolina State University
NIEHS Postdoctoral Fellow, Duke University

Research Interests

Dr. McClellan-Green's research focuses on the study of natural and man-made toxins in the marine environment and their effects on the metabolic activities of marine organisms. Biochemical and health effects of exposure to anthropogenic c ompounds, contaminants and toxins can drastically alter the development, metamorphosis, reproductive capacity or ability of exposed organisms to utilize nutritional sources. The consequences of exposure to these anthropogenic compounds may be reduced water quality, declines in available habitat, decreases of vital fisheries (both finfish and shellfish) and human health effects related to ecosystem exposure. Current research themes include (1) examination of the molecular and biochemical pathways involved in endocrine production, metabolism and environmental disruption, (2) the effects of anthropogenic exposure on uptake, distribution and metabolism including oxidative stress in marine/estuarine species (3) determining the effects and consequences of exposure to antifouling compounds and booster biocides on non-target species and (4) the characterization of detoxification pathways (cytochrome P450s) in marine species.

 


Selected Publications

  • Blickley, T. Michelle and Patricia McClellan-Green (in preparation). Ecotoxicity of Fullerene Suspensions (nC 60 ) in Adult and Larval Fundulus heteroclitus .

  • Romano, Jocelyn A., Rittschof, Daniel, McClellan-Green, Patricia and Eric R. Holm (in preparation). Variation in toxicity of copper pyrithione among populations and families of the barnacle, Balanus amphitrite

  • McClellan-Green, Patricia D ., Oberdörster, Eva, Zhu, Shiqian, Blickley , T. Michelle and Mary L. Haasch . (2007). Impact of Nanoparticles on Aquatic Organisms. In Nanoparticles: Characterization, Dosing and Health Effects. (Eds)N. Monteiro-Riviere and C. L. Tran, Taylor & Francis, CRC Press, New York , NY . pp 391-404.

  • Burger, Joanna, Fossi, Cristina, McClellan-Green, Patricia and Edward F. Orlando (2007). Assessment of approaches and methodologies for gender-related differences in wildlife and the environment. Environ. Res. 104: 135-152.

  • McClellan-Green, Patricia , Romano, Jocelyn and Eva Oberdörster. (2007) Does gender really matter in contaminant exposure? A case for invertebrate risk assessment. Environ. Res. 104: 183-191.

  • Oberdörster, Eva, McClellan-Green, Patricia and Mary Haasch (2006). Ecotoxicity of engineered nanomaterials. In Wiley-VCH Book Series on Nanotechnology for Life Sciences, Vol. 5, Nanomaterials-Toxicity, Health and Environmental Issues.

  • McClellan-Green , Patricia , Romano, Jocelyn and Daniel Rittschof (2006). Imposex Induction in the Mud Snail, Ilyanassa obsoleta By Three Tin Compounds. Bull. Environ. Cont. Toxicol. 76: 581-588.

  • Oberdörster, Eva, Zhu, Shiqian, Blickley, T. Michelle, McClellan-Green, Patricia and Mary L. Haasch (2006). Ecotoxicology of Carbon-Based Engineered Nanoparticles: Effects of Fullerene (C60) on aquatic organisms. Carbon 44:1112-1120.

  • Keller, Jennifer M., McClellan-Green, Patricia D ., Kucklick, John R., Keil, Deborah E. and Margie M. Peden-Adams (2006) Effects of Organochlorine Contaminants on Loggerhead Sea Turtle Immunity: Comparison of a Correlative Field Study and In Vitro Exposure Experiments. Environ. Hlth. Prespec. 114(1): 70-76.

  • McClellan-Green, P., Celander, M. and E. Oberdorster (2005). Hepatic, Renal and Adrenal Toxicology in Reptile Toxicology, Gardner, S. and E. Oberdorster (eds), CRC Press, LLC, pp 103-124.

  • Keller, Jennifer M., McClellan-Green, Patricia D., Lee, A. Michelle, Arendt, Mike D., Maier, Philitp P., Segars, Al L., Whitaker, J. David, Keil, Deborah E. and Margie M. Peden-Adams (2005). Mitogen-induced lymphocyte proliferation in loggerhead sea turtles: comparison of methods and effects of gender, plasma testosterone concentration and body condition on immunity. Vet. Immunol. Immunopath. 103: 269-281.

  • Rittschof, Daniel and McClellan-Green, Patricia (2005). Mollusks as Multidisciplinary Models in Environment Toxicology. Mar. Pol. Bull. 50(4): 369-373.

  • Oberdorster, Eva, Romano, Jocelyn and Patricia McClellan-Green (2005). The neuropeptide APGWamide as a Penis Morphogenic Factor (PMF) in gastropod mollusks. Integrative and Comparative Biology 45 (1): 28-32.

  • Haasch, Mary L., McClellan-Green, Patricia , and Eva Oberdörster (2005). Consideration of the toxicity of manufactured nanoparticles. In XIX International Winterschool/Euroconference on Electronic Properties of Novel Materials (H. Kuzmany, J. Fink, M. Mehring and S. Roth, eds.), Vol. 786, pp. 586-589. American Institute of Physics (AIP), Kirchberg, Tirol , Austria .

  • Keller, Jennifer M., John R. Kucklick, M. Andrew Stamper, Craig A Harms, Patricia McClellan-Green (2004). Are organochlorine contaminants affecting the clinical health of loggerhead sea turtles? Environ. Hlth Perspec. 112(10): 1074-1079.

  • Keller, J.M., J. R. Kucklick and P. McClellan-Green (2004). Organochlorine Contaminants in Loggerhead Sea Turtle Blood: Extraction Techniques and Distribution among Plasma and Red Blood Cells. Arch. Environ. Contam. Toxicol.46: 254-264.

  • Balmer-Hanchey, E.L., Jaykus, L.A., Green, D. P. and P. McClellan-Green, 2003, Marine Biotoxins of Algal Origin and Seafood Safety, Journal of Aquatic Food Product Technology, 12: 29-54.

  • Oberdörster E, P McClellan-Green. 2002. Mechanisms of imposex induction in mud snail, Ilyanassa obsoleta: TBT as a neurotoxin and aromatase inhibitor. Marine Environmental Research. 54(3-5): 715- 718.

  • Oberdörster, E. and P. McClellan-Green. (2000) The neuropeptide APGWamide induces imposex induction in the mud snail, Ilyanassa obsoleta. Peptides 21:1323-1330.

  • Keller, J.M., C.A. Harms, S. Kennedy-Stoskopf and P. McClellan-Green. (2000) Isolation and Proliferation of Peripheral Blood Mononuclear Cells from the Loggerhead Sea Turtle (Caretta caretta): Techniques and Applications. Proceedings of the 10th Annual Sea Turtle Symposium. Vol. 20: 103-105.

Related Web Sites

http://www.cmast.ncsu.edu