Mailing
address:
Department of Environmental
and Molecular Toxicology
Box 7633, NC State University
Raleigh, NC 27695-7633
Shipping
address:
Suite 1104, 850 Main Campus Dr.
Raleigh, NC 27606
Phone
919.515.2274
Fax 919.515.7169
Ernest
Hodgson, Ph.D.
Distinguished Professor Emeritus
Department of Environmental and Molecular Toxicology
Phone: 919-515-5295
E-mail: ernest_hodgson@ncsu.edu
Many
toxicologists know Dr Hodgson as one of the authors of two widely
used textbooks of toxicology, "A Textbook of Modern Toxicology" and
"An Introduction to Biochemical Toxicology", others as the editor
of the "Journal of Biochemical and Molecular Toxicology" and
"Macmillan's Dictionary of Toxicology" and through his public
and professional service activities with governmental agencies and
societies such as the International Society for the Study
of Xenobiotics and the Society of Toxicology.
Research Interests
- Human Metabolism of Environmental Chemicals
- Human Populations at Risk
- Chemicals Associated with Natural Ecosystems, Agriculture, Industry, Military Deployments and Domestic Environments
Studies of the human metabolism of xenobiotics through molecular and biochemical techniques contribute to a scientific approach to risk assessment of environmental chemicals and to knowledge of interactions between toxicants. Further, through the study of genetic polymorphisms, such studies may lead to the identification of populations at increased or reduced risk from chemical contamination. During the last eight years, my group, along with a number of collaborators, have published extensively on the phase I metabolism in humans of such compounds as the agrochemicals, chlorpyrifos, carbaryl, carbofuran and fipronil, the jet fuel components, nonane and naphthalene, and the repellent, DEET. Interactions of potential importance to human health, based on inhibition of cytochrome P450 isoforms, have been described, most notably the potent inhibition of both testosterone and estradiol metabolism by chlorpyrifos, phorate and other organophosphorus chemicals. Studies utilizing human hepatocytes are concerned with both cytotoxicity and the induction of xenobiotic-metabolizing enzymes.
Selected Publications
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K. A. Usmani, T. M. Cho, R. L. Rose and E. Hodgson . 2006. Inhibition of the human liver microsomal and human cytochrome P450 1A2 and 3A4 metabolism of estradiol by deployment-related and other chemicals. Drug Metabol. Disp. 34:1606-1614.
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P.C. Das, Y. Cao, N. Cherrington, E. Hodgson and R.L. Rose. 2006. Fipronil induces CYP isoforms in human hepatocytes. Chemico-Biological Interactions. 164: 200-214.
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R. C. T. Casabar, A. A. Wallace, E. Hodgson and R. L. Rose. 2006. Metabolism of endosulfan-alpha by human liver microsomes and its utility as a simultaneous in vitro probe for CYP2B6 and CYP3A4. Drug Metabol. Disp. 34: 1606-1614.
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Hodgson, E. and Rose, R. L. 2007. The importance of cytochrome P450 2B6 (CYP2B6) in the human metabolism of environmental chemicals. Pharmacol. Therap. 113: 420-428.